This is a 3-year University of Oxford/Celgene PhD position in the laboratory of Dr Paresh Vyas. This project involves the study of key differences in the epigenetic state of human leukaemic and normal blood stem cells. Furthermore, the successful candidate will study the mechanism of action of a new class of epigenetic-targeted current anti-leukaemic therapy to determine how best to use this therapy in leukaemia, and cancer more broadly. The studentship will provide high-class training in cutting-edge molecular and cellular biology of normal and leukaemic stem cells. This position will especially suit a graduate with a biochemistry or biology degree with molecular and cellular biology content. An interest in cancer, stem cell biology and epigenetics will be important.
The Vyas laboratory currently consists of four postdoctoral scientists, one postdoctoral Clinical Fellow, two PhD students and one graduate research assistant. The laboratory is part of the MRC Molecular Haematology Unit (MHU). The common research theme of the Unit is the study of the molecular mechanisms that underpin normal haemopoietic differentiation. More information can be obtained about the MRC Unit on the web at (www.imm.ox.ac.uk/mhu) and the Vyas lab in (www.imm.ox.ac.uk/mhu/Group_Pages/Vyas).
Further information including terms and conditions may be obtained from Paresh Vyas by e-mail paresh.vyas@imm.ox.ac.uk or telephone 01865 222309.
To apply, please send a letter of application with a detailed CV including the contact details of three referees to: Carol Eaton, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, or email carol.eaton@imm.ox.ac.uk
Closing date for applications: Friday 20 November 2009
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